Whole cell and enzymatic production of aldehydes and their biocompatible conversion to dinitroalkanes

Show simplified metadata
dc.contributor.advisorDomaille, Dylan
dc.contributor.authorHawkins, Kendyll G.
dc.contributor.committeememberKlein-Seetharaman, Judith
dc.contributor.committeememberSpear, John R.
dc.contributor.committeememberTrewyn, Brian
dc.date.accessioned2022-10-13T21:46:21Z
dc.date.available2022-10-13T21:46:21Z
dc.date.issued2022
dc.date.updated2022-10-01T01:11:56Z
dc.descriptionIncludes bibliographical references.
dc.description2022 Spring.
dc.description.abstractAldehydes are commonly used as intermediates in chemical syntheses or directly in pharmaceuticals or as flavors and fragrances. However, their isolation from plants is resource intensive, and their synthetic preparation requires harsh operating conditions. Emerging efforts have focused the production of bio-aldehydes via enzymatic oxidation, reduction, or via de novo metabolic pathways. Here, we catalog the different ways to synthesize aldehydes with enzymatic and whole-cell systems. We further describe their one-pot conversion to dinitroalkanes via a novel 4-step hybrid enzymatic and organocatalytic reaction cascade.
dc.identifierHawkins_mines_0052N_12392.pdf
dc.identifierT 9338
dc.identifier.urihttps://hdl.handle.net/11124/15421
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado School of Mines. Arthur Lakes Library
dc.relation.ispartof2022 - Mines Theses & Dissertations
dc.rightsCopyright of the original work is retained by the author.
dc.subjectalcohol oxidase
dc.subjectaldehydes
dc.subjectbioproduction
dc.subjectbiosynthesis
dc.subjectdinitroalkane
dc.subjectnitroalcohol
dc.titleWhole cell and enzymatic production of aldehydes and their biocompatible conversion to dinitroalkanes
dc.typeText
dspace.entity.typePublication
thesis.degree.disciplineChemistry
thesis.degree.grantorColorado School of Mines
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hawkins_mines_0052N_12392.pdf
Size:
1.62 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.33 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
2022 - Mines Theses & Dissertations