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dc.contributor.advisorKrebs, Melissa D.
dc.contributor.advisorPantcheva, Mina B.
dc.contributor.authorOsmond, Matthew J.
dc.date.accessioned2019-10-03T21:27:50Z
dc.date.accessioned2022-02-03T13:17:45Z
dc.date.available2019-10-03T21:27:50Z
dc.date.available2022-02-03T13:17:45Z
dc.date.issued2019
dc.identifierOsmond_mines_0052E_11803.pdf
dc.identifierT 8790
dc.identifier.urihttps://hdl.handle.net/11124/173274
dc.descriptionIncludes bibliographical references.
dc.description2019 Summer.
dc.description.abstractBiomedical research has led to many advancements in healthcare for the treatment, diagnosis and monitoring of many diseases. Tissue engineering is a discipline within biomedical research that combines engineering principles with biology to understand and recreate tissues and complex cellular structures. This thesis focuses on the work done to understand a variety of different diseases by monitoring the cellular responses of tissue specific cells on biomimetic materials or by tuning material properties to obtain a desired cellular response. To study glaucoma, a biomimetic scaffold was produced to replicate the native trabecular meshwork tissue and changes to cell behavior was monitored by measuring proliferation, protein expression, and migration throughout the scaffold. This work led to the development of biomimetic bone grafts of the same collagen material which was then used to characterize cellular behavior through proliferation and osteoinductive potential. Finally, this work led to the ration design of a dental composite that could impart fast setting, mechanically strong, biocompatible, and odontoinductive properties that would lead to the regeneration of dental tissue. The combination of these works helps to further the understanding of three separate diseases by characterizing and manipulating how cells in each system interact specifically with their native environment.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado School of Mines. Arthur Lakes Library
dc.rightsCopyright of the original work is retained by the author.
dc.subjectglaucoma
dc.subjecttissue engineering
dc.subjectpulp capping
dc.subjectbone grafts
dc.titleImplementation of biomaterials to study and control complex cell behaviors
dc.typeText
dc.contributor.committeememberChauhan, Anuj
dc.contributor.committeememberNeeves, Keith B.
dc.contributor.committeememberKnauss, Daniel M.
thesis.degree.nameDoctor of Philosophy (Ph.D.)
thesis.degree.levelDoctoral
thesis.degree.disciplineChemical and Biological Engineering
thesis.degree.grantorColorado School of Mines


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