• Login
    View Item 
    •   Home
    • Theses & Dissertations
    • 2012 - Mines Theses & Dissertations
    • View Item
    •   Home
    • Theses & Dissertations
    • 2012 - Mines Theses & Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Mines RepositoryCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    Login

    Mines Links

    Arthur Lakes LibraryColorado School of Mines

    Statistics

    Display Statistics

    Characterization of organosilane-modified silicon/silicon dioxide systems for biological and nanotechnology applications

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Shircliff_mines_0052E_10086.pdf
    Size:
    11.27Mb
    Format:
    PDF
    Description:
    Characterization of organosila ...
    Download
    Author
    Shircliff, Rebecca
    Advisor
    Cowley, Scott W.
    Date issued
    2012
    Date submitted
    2012
    Keywords
    nanoparticles
    XPS
    DNA microarray
    silicon
    silane
    DNA microarrays
    Nanotechnology
    Silane compounds
    Silicon
    Silica
    
    Metadata
    Show full item record
    URI
    https://hdl.handle.net/11124/79460
    Abstract
    Silane functionalization of Si/SiO2 systems is a versatile technique that can be used in DNA microarray and nanotechnology applications. Control of the composition, chemistry and structure of the underlying silane film is crucial for optimization of the final devices. In this dissertation, aminosilanes and alkysilanes are investigated for applications in DNA microarrays and nanoparticle modification. Innovative methods are used to quantify the composition of these silane films, including X-ray photoelectron spectroscopy. In addition, low-temperature-plasma grown Si nanoparticles are modified for the first time using self-limited silanization techniques. Mixed silane monolayers provide a method for controlling DNA attachment via dilution of amine density. DNA hybridization results suggest these films are restrictive, thus reducing DNA hybridization efficiencies. To investigate the effect of the silane film structure on DNA hybridization, three distinct aminosilane films were generated: 1) a self-limited monolayer, 2) a 1-2 layer film and 3) a thick, multilayer film. DNA radiometric assays show restriction of DNA hybridization by the self-limited monolayer and high DNA hybridization efficiencies on the 1-2 layer film, demonstrating the important role the silane film structure plays in DNA microarray efficacy. This silane chemistry is extended to Si nanoparticles to improve their suitability for nanotechnology applications. Specifically, Si nanoparticles are modified with a monolayer-thick alkylsilane film, making them stable for over two months in air, and producing a colloidal suspension of the particles. The size, stability and colloidal suspension of these Si nanoparticles distinguish them as useful components for nanotechnology applications, such as light-emitting diodes, biological sensors and markers, and photovoltaics.
    Rights
    Copyright of the original work is retained by the author.
    Collections
    2012 - Mines Theses & Dissertations

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.