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    Development of 166Ho skin patch to treat skin diseases with 1 MW TRIGA reactor

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    Development of 166Ho skin patch ...
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    Author
    Morneau, Rachel A.
    Advisor
    Sarazin, Frederic
    Date issued
    2014
    Date submitted
    2014
    Keywords
    holmium
    cancer
    TRIGA
    sputter
    skin
    patch
    Skin -- Diseases -- Radiotherapy
    Skin -- Cancer -- Radiotherapy
    Radioisotopes
    Holmium
    Irradiation
    TRIGA reactors
    
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    URI
    http://hdl.handle.net/11124/444
    Abstract
    Isotopes from the lanthanide series are suitable for intense localized radiotherapy of tumors and melanomas. [superscript 166]Ho is a promising radioisotope for use in medical radiotherapy due to its relatively short half-life of 26.8 hours and emission of high-energy [beta]-particles. [superscript 166]Ho can be produced in suitable quantities using the USGS 1 MW TRIGA reactor located at the Denver Federal Center. A prototype patch was created by RF sputtering holmium oxide onto Kapton foil. The prototype patch showed that [beta]-particles have good penetration and rapid fall-off in the photographic paper. A few short comings were observed in the prototype holmium radiotherapy patch. The current RF sputtering process is slow and non-uniform. This may be due to using a holmium oxide target instead of a holmium metal target. Delamination was observed in some of the prototype patches. A design that contains the holmium deposition will be necessary. The activity and the presence of contaminants were analyzed using gamma-spectra dominated by an 80.6 keV gamma-ray. Irradiation and measurements of a holmium oxide radiotherapy patch that was sputtered for 1 h at 150 W show an activity of 7.03 [plus-minus sign] 0.35 [mu]Ci. Error is largely due to the error in the calibrated sources as well as inaccuracies from systematic error in the solid angle measurements and statistical error in measuring counts.
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