Show simple item record

dc.contributor.advisorAyers, Reed A.
dc.contributor.authorVollmer, Nina
dc.date.accessioned2007-01-03T06:27:58Z
dc.date.accessioned2022-02-09T08:59:13Z
dc.date.available2015-04-01T04:18:44Z
dc.date.available2022-02-09T08:59:13Z
dc.date.issued2014
dc.date.submitted2014
dc.identifierT 7523
dc.identifier.urihttp://hdl.handle.net/11124/436
dc.description2014 Spring.
dc.descriptionIncludes illustrations (some color).
dc.descriptionIncludes bibliographical references (pages 96-109).
dc.description.abstractSynthetic calcium phosphate (CaP) materials exhibit unique chemical, biological and physical properties. Subsequently, they are routinely used as bone graft substitute materials. There is significant demand for a reliable synthesis technique that can rapidly produce bioactive CaP biomaterials[1-4]. The purpose of this research was to evaluate the potential of specific combustion synthesis (CS) techniques: Self-propagating high-temperature synthesis (SHS) and decomposition combustion synthesis (DCS) for the production of CaP constructs and powders and to clarify the relationships between CS reactant properties, reaction parameters and product properties. CS reactions are highly versatile; reactant composition and stoichiometry can be modified to incorporate specific atoms or ions into the final products to enhance mechanical performance, specific material properties, bioactivity and functionality in vivo. SHS reactant composition and reactant stoichiometry were modified to generate porous three-dimensional CaP scaffolds substituted with silver (Ag), strontium (Sr), magnesium (Mg), [beta]-tricalcium phosphate (TCP) or reacted hydroxyapatite (HA). Post-synthesis, 100 TCP constructs were heat treated and coated with collagen, alginate or chitosan to produce CaP-based composite devices. Product composition, morphology and mechanical properties were characterized to elucidate the effects of altering reactant composition and stoichiometry on product properties. Antimicrobial performance of the CaP-Ag constructs was assessed against Escherichia coli, while cytotoxicity, biocompatibility and biologic response to the CaP-Ag constructs were assessed with a human fetal osteoblast cell line (ATCC, CRL-11372). DCS reactant ratio was modified to generate CaP biopowders with specific chemistries. Product composition and morphology were analyzed and in vitro testing methods were utilized to determine the effects of controlling product composition on cytotoxicity, proliferation, biocompatibility and biomineralization. SHS and DCS represent manufacturing methods that can be utilized to synthesize CaP constructs and biopowders for use in bone tissue engineering applications.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado School of Mines. Arthur Lakes Library
dc.relation.ispartof2014 - Mines Theses & Dissertations
dc.rightsCopyright of the original work is retained by the author.
dc.subjectbone
dc.subjectcalcium phosphate
dc.subjectbone graft substitute materials
dc.subjectcombustion synthesis
dc.subjecttissue engineering
dc.subject.lcshSelf-propagating high-temperature synthesis
dc.subject.lcshCalcium phosphate
dc.subject.lcshBone-grafting -- Materials
dc.subject.lcshBiomedical materials
dc.titleCombustion synthesis: self-propagating high-temperature synthesis (SHS) and decomposition combustion synthesis (DCS) for production of calcium phosphate biomaterials
dc.typeText
dc.contributor.committeememberCowley, Scott W.
dc.contributor.committeememberLiang, Hongjun
dc.contributor.committeememberTaylor, Patrick R.
dc.contributor.committeememberKing, Karen
dc.contributor.committeememberPatel, Vikas
dcterms.embargo.terms2015-04-01
dcterms.embargo.expires2015-04-01
thesis.degree.nameDoctor of Philosophy (Ph.D.)
thesis.degree.levelDoctoral
thesis.degree.disciplineMetallurgical and Materials Engineering
thesis.degree.grantorColorado School of Mines
dc.rights.access1-year embargo


Files in this item

Thumbnail
Name:
Vollmer_mines_0052E_10440.pdf
Size:
7.619Mb
Format:
PDF
Description:
Combustion synthesis : self-pr ...

This item appears in the following Collection(s)

Show simple item record