Investigating the underlying mechanisms of type 1 diabetes: how changes in the extracellular matrix affect pancreatic islet function

Abstract

Over the past decade, knowledge of the pathogenesis and pathophysiology of type 1 diabetes has grown substantially, and technological devices, such as glucose monitors and insulin pumps, have improved to allow patients to better manage the difficulties of living with type 1 diabetes. However, despite these improvements, managing diabetes remains a challenging, daily task that requires constant vigilance and focus. Thus, the ultimate goal is to discover a biological cure for type 1 diabetes, to relieve people of these burdens and help them return to their normal lives.