Recent Submissions

  • Unveiling hidden viral host protein interactions in COVID-19 for drug repurposing

    Ovanessians, Armand
    In the absence of effective antiviral drugs for the treatment of COVID-19, we designed a novel k-partite graph learning method for data matrix completion to uncover hidden viral-host interactions and drug-target interactions. Our framework produces a holistic map of the pathogenesis of COVID-19 and unveils novel FDA approved drug candidates for COVID-19.
  • Investigating the underlying mechanisms of type 1 diabetes: how changes in the extracellular matrix affect pancreatic islet function

    Sela, Amit
    Over the past decade, knowledge of the pathogenesis and pathophysiology of type 1 diabetes has grown substantially, and technological devices, such as glucose monitors and insulin pumps, have improved to allow patients to better manage the difficulties of living with type 1 diabetes. However, despite these improvements, managing diabetes remains a challenging, daily task that requires constant vigilance and focus. Thus, the ultimate goal is to discover a biological cure for type 1 diabetes, to relieve people of these burdens and help them return to their normal lives.
  • Improving an algorithm for quantum computers

    Varosy, Paul
    Quantum computers have the possibility to transform the world due to their applications in drug discovery, artificial intelligence, cyber-security, materials science, and more. However, there are still a few hurdles researchers need to cross before quantum computers can revolutionize these fields. One area of active research is to develop quantum algorithms: specifically applying quantum computers to real-world problems.
  • Interview with Dr. Paulo Cesar Tabares-Velasco

    Jones, Mackenzie
    Dr. Tabares-Velasco is an associate professor in the Mechanical Engineering Department. He earned his Bachelor's in Engineering Physics at Monterrey Institute of Technology where he found his passion in energy science. He moved to Colorado State University for his Master's in Mechanical Engineering before receiving his PhD in Architectural Engineering at Pennsylvania State University. His research includes building envelopes, thermal storage, building and community integration with the smart grid. Dr. Tabares is passionate about working to provide energy efficiency to low-income homes as well as sparking students' interest in energy through the SE@M program and his research group, AMBER.
  • Measuring the surface roughness and surface energy of carbon steel pipes to understand hydrate-solid adhesion

    Chase, Bella
    Gas hydrates are ice-like solids that occur when small, nonpolar gas molecules, such as methane or carbon dioxide, are trapped within a crystalline structure of water molecules under conditions of low temperature and high pressure [1]. These conditions often exist in subsea oil and gas pipelines and the aggregation/deposition of hydrates leads to blockages, which stop oil and natural gas transportation and poses subsequent environmental hazards. Not only do hydrate plugs create pressure build ups, but in some cases upon removal hydrate projectiles erupt from the pipe rupture. Solid surface characteristics, including the average surface roughness and surface energy, have been shown to impact the adhesive strength of the ice/solid interface in the literature. It is likely that such parameters also affect the adhesive strength of the hydrate/solid interface. By quantifying the surface roughness and surface energy of carbon steel pipes using contact profilometry measurements and goniometry, we can better understand the effects of these parameters on hydrate/solid adhesion and the potential impact on flow assurance.
  • High entropy metal oxides as catalyst for water splitting

    Kelly, Zek
    Water splitting is a chemical reaction that takes water (H2O) and breaks it down into its elemental components. Hydrogen gas (H2) and oxygen gas (O2). This reaction is one of the "holy grails" of science because, in theory, it is a reaction who's [sic] only products are clean fuel and breathable air.
  • Interview with Dr. Svitlana Pylypenko

    Hoffmann, Maddy
    Dr. Pylypenko has been a faculty member at Colorado School of Mines for over 13 years. Originally from Ukraine, she has studied at the Kyiv Polytechnic Institute, Kent State University, and the University of New Mexico where she received her Ph.D. in Chemistry. She is currently a professor and researcher in the Chemistry department here at Mines studying surfaces and interfaces of functional materials. Her group focuses largely on researching fuel cells and electrolyzers; these two complementary technologies are critical to our renewable energy future.
  • Reuleaux undergraduate research journal: fourth edition

    Hoffmann, Maddy; Strongman, Grace; Nunez, Sergio; Ashton, Emmelia; Jones, Mackenzie; Kelly, Zek; Chase, Bella; Sela, Amit; Ovanessians, Armand; Varosy, Paul
  • Systematic analysis of low-energy 7Be decay spectra in superconducting quantum sensors under the study of electron shaking effects

    Nunez, Sergio
    In the present article, we report the systematic analysis of the low energy Beryllium-7 (7Be) nuclear electron capture decay spectra for different pixels in the BeEST experiment under the study of the Electron Shaking Effect (ESE). This analysis was performed fixing the ESE probability, known as Shaking Probability (SP), in the L-capture peak from 5% to 30% and then running the BeEST analysis code. We found a fitting consistency between both pixels at 15% of SP, which is in agreement with previous BeEST spectrum analysis works, but with discrepancies in the modeling and fitting parameters (χ2v = 1.83 for pixel 4 and χ2v = 1.85 for pixel 5). Discrepancies are discussed to improve modeling and fitting methods for next BeEST phases.
  • Potential use of nanostructured surfaces and metallic nanoparticles to combat the spread of infectious diseases, The

    Ashton, Emmelia
    In recent years, serious health problems have been caused by the increasing resistance of pathogens to traditional antibiotics [1]. The development of novel, effective, and improved antimicrobial agents is necessary to prevent the spread of illness and pathogens. Copper possesses natural antimicrobial properties. However, its use as an antibacterial agent is not common due to the low rate of antimicrobial activity compared to traditional antimicrobial agents. Recent advances in the understanding of naturally biocidal surfaces have contributed to the development of nanopatterning technology that can be used to increase the antimicrobial effect of metallic substrates. The surface channelization of copper powder and mesh was performed to determine whether the natural biocidal properties of copper could be enhanced using nano-structuring techniques to create nanoscale channels across the surface. An in vitro trial of the nanochannelized copper powder against the Pseudomonas virus, Phi6, demonstrated an increase in the antimicrobial potential. These results suggest etching can be used to influence the geometry of surface features and improve the antimicrobial properties of naturally biocidal materials. The increased biocidal effect of the copper substrate could be implemented in numerous applications to help combat the growing issue of bacterial resistance and limit the spread of infectious disease.