• Login
    View Item 
    •   Home
    • Theses & Dissertations
    • 2018 - Mines Theses & Dissertations
    • View Item
    •   Home
    • Theses & Dissertations
    • 2018 - Mines Theses & Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Mines RepositoryCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    Login

    Mines Links

    Arthur Lakes LibraryColorado School of Mines

    Statistics

    Display Statistics

    Synthesis of poly(lactide)-based amphiphilic block copolymers and hydroxyapatite nanoparticles for bone tissue engineering applications

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Smith_mines_0052E_11646.pdf
    Size:
    15.34Mb
    Format:
    PDF
    Download
    Author
    Smith, Patrizia P.
    Advisor
    Boyes, Stephen G.
    Date issued
    2018
    Keywords
    electrospinning
    scaffolds
    amphiphilic block copolymers
    tissue engineering
    poly(lactide)
    
    Metadata
    Show full item record
    URI
    https://hdl.handle.net/11124/172825
    Abstract
    Due to the drawbacks associated with traditionally used bone substitutes, such as autografts and allografts, the field of tissue engineering, regenerative medicine and biomaterials science has recently come to the forefront with new strategies for bone repair and de novo tissue formation. Current research has focused on employing bionanocomposites composed of polymers, such as poly(lactide) (PLA), and inorganic calcium phosphate ceramics, such as hydroxyapatite (HA). These hybrid materials benefit from combining biodegradability, biocompatibility, bioactivity, and other advantageous scaffold properties to better mimic biological and structural characteristics of native bone. With this in mind, the work presented in this dissertation focuses on the synthesis of well-controlled PLA homopolymers, as well as amphiphilic block copolymers. This was achieved via the ring opening polymerization (ROP) of lactide using an organocatalyst and the successful combination of ROP of lactide and the reversible addition-fragmentation chain transfer (RAFT) polymerization of poly(ethylene glycol) ethyl ether methacrylate (PEGEEMA) using a novel heterofunctional initiator/chain transfer agent (inifer). Comprehensive kinetics studies also provided valuable insights into the factors influencing the synthesis of well-defined block copolymers. These polymers were then successfully processed into fibrous scaffolds using electrospinning techniques and the different parameters affecting fiber formation and morphology were investigated. In addition, the prepared scaffolds were evaluated in terms of overall hydrophilicity, in vitro performance, and biodegradation behavior. Furthermore, a hydrothermal synthesis approach was employed to produce well-defined HA nanoparticles with tunable sizes that can be used in biomimetic nanocomposite scaffolds. Lastly, the surface modification of the HA nanoparticles was investigated via a grafting-from approach using the ROP of lactide, as well as via the use of a poly(dopamine) coating. Overall, the results presented in this dissertation provide important mechanistic insights into the successful synthesis of well-controlled amphiphilic block copolymers and also contribute to developing facile methods to prepare biomimetic HA nanoparticles and biodegradable fiber scaffolds. The findings also further highlight the importance of polymer and nanoparticle-containing bionanocomposite scaffolds, which have the potential to greatly improve the treatment of bone defects and bone loss.
    Rights
    Copyright of the original work is retained by the author.
    Collections
    2018 - Mines Theses & Dissertations

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.