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Fabricate mesoporous silica nanoparticles with iron core for transporting organometallic cataysts and exogenous enzymes
Raizada, Rewa Kovach, Nolan C. Smith, Jaclyn Trewyn, Brian G.
Raizada, Rewa
Kovach, Nolan C.
Smith, Jaclyn
Trewyn, Brian G.
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2024-04
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Abstract
The objective of this research is to design and fabricate multifunctional mesoporous materials with an iron core to hold and transport paramagnetic molecular catalysts and biocatalysts that are capable of synthesizing advanced molecules in intracellular environments. Mesoporous Silica Nanoparticles (MSN) have a large surface area and can be used as drug carriers. Amine functionalization of MSN helps with dispersion, while paramagnetic component can assist in directed drug delivery under external magnetic field. Two distinct methods were employed for the manufacture of the nanocarriers: a co-precipitation and a solvothermal method. Both methods resulted in high surface area material with ordered, uniform pores. We will discuss the findings and material properties of both types of materials along with discussing applications for magnet-responsive mesoporous materials.
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