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Quantifying metabolic fluxes using transient stable isotope labels
Sake, Cara L.
Sake, Cara L.
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2022
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2023-11-04
Abstract
The desire to apply engineering principles to biological systems has been a primary research objective for thousands of applications across a multitude of disciplines: from genetic engineering for the manufacture and production of biofuels, pharmaceuticals, and specialty chemicals, to systems biology approaches for characterizing and understanding health, disease, and other biological phenomena. As we strive for a more sophisticated understanding and subsequent utilization of these biological systems, it is imperative that equally complex tools for probing cellular metabolism be established simultaneously. My dissertation work focuses first on the development of experimental and analytical techniques to inform fundamental models that quantify reaction-level metabolism of non-model organisms and then apply these techniques to address real-world systems biology and metabolic engineering challenges.
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