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Active porous supports for industrializing enzymes: optimization of the cobalt phosphate nanoparticle synthesis
Hughes, Davin V. Oostenrijk, Tanja R. von Brandt, Richard Berstler, Calvin Trewyn, Brian
Hughes, Davin V.
Oostenrijk, Tanja R.
von Brandt, Richard
Berstler, Calvin
Trewyn, Brian
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2025-04
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Abstract
Multi-step chemoenzymatic catalysis within a single reaction vessel is a difficult task. A chemoenzymatic process describes a category of reactions where two or more consecutive transformations occur in a single reaction vessel making for more efficient post-reaction processing. Enzymatic and chemical catalysis are employed to generate products from commercially available starting materials efficiently by removing the step of isolating intermediates. Due to the current interest in designs for biosynthetic materials that employ inorganic materials and enzymes within one-pot systems, the development of catalytically active mesoporous nanomaterials as enzyme supports harbors the potential to enhance the usability and performance of the combined catalysts. In this work, we examine the material properties that influence the catalytic activity of metal phosphate materials while working to optimize the synthesis conditions of both bulk and mesoporous metal phosphate materials considering both crystallinity and surface areas. Optimization of this synthesis includes the impact of synthesis and aging temperatures, and the use of different surfactants on material properties and morphology of cobalt phosphate materials. Catalases, which are known for their proficiency in decomposing hydrogen peroxide in biological systems, are used in a wide range of applications such as in medicine, catalysis, and environmental remediation. Large pore mesoporous cobalt phosphate provides an increased surface area and has shown potential for the synthesis of keto acids. Further work regarding this is needed to determine whether we can covalently immobilize enzymes such as L-amino acid oxidase within the pores of cobalt phosphate, though initial results look promising.
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