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Development of zwitterionic hydrogels for sustained drug release
Raichart, Alexandra C.
Raichart, Alexandra C.
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2023
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The biomedical field contains many diverse applications, such as; tissue engineering, biomolecules immobilization, drug delivery, and wound dressings. This thesis focuses on a combination of two of its applications, drug delivery and wound dressings. It is well documented within the literature that hydrogels show a lot of promise as wound dressings that can be loaded with and release drugs over long periods of time. Their ability to not only provide protection from the outside environment but also release a wide variety of drugs directly to the site of the wound makes them a desirable possibility for treating chronic wounds. Chronic wounds, specifically those associated with diabetes, are often complicated by over inflammation, and require treatment to fully repair themselves. This work led to the development of multiple types of zwitterionic hydrogels for sustained drug releases over the course of three main projects. Sustained release of multiple molecule types was achieved using the three different hydrogel types. The characterization of these hydrogels is outlined within this thesis. The combination of all these projects provides flexibility when determining the best wound dressing for a variety of applications. Each hydrogel varies in its composition and properties and therefore allows for the tuning of the wound dressing to better fit the specific wound being treated.
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