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Potential use of nanostructured surfaces and metallic nanoparticles to combat the spread of infectious diseases, The
Ashton, Emmelia
Ashton, Emmelia
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2023-11
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Abstract
In recent years, serious health problems have been caused by the increasing resistance of pathogens to traditional antibiotics [1]. The development of novel, effective, and improved antimicrobial agents is necessary to prevent the spread of illness and pathogens. Copper possesses natural antimicrobial properties. However, its use as an antibacterial agent is not common due to the low rate of antimicrobial activity compared to traditional antimicrobial agents. Recent advances in the understanding of naturally biocidal surfaces have contributed to the development of nanopatterning technology that can be used to increase the antimicrobial effect of metallic substrates. The surface channelization of copper powder and mesh was performed to determine whether the natural biocidal properties of copper could be enhanced using nano-structuring techniques to create nanoscale channels across the surface. An in vitro trial of the nanochannelized copper powder against the Pseudomonas virus, Phi6, demonstrated an increase in the antimicrobial potential. These results suggest etching can be used to influence the geometry of surface features and improve the antimicrobial properties of naturally biocidal materials. The increased biocidal effect of the copper substrate could be implemented in numerous applications to help combat the growing issue of bacterial resistance and limit the spread of infectious disease.
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